01 March 1996
Blood levels of plasminogen and alpha-2-antiplasmin in patients with prostatic carcinoma
Izabela Iwan-Ziętek, Maria Kotschy, Ewa Wiśniewska, Zbigniew WolskiMed Sci Monit 1996; 2(2): CR183-186 :: ID: 499563
Abstract
Activation of fibrinolysis resulting in bleeding was observed in patients with prostatic carcinoma. The aim of this study was to estimate the level of plasminogen, a precursor of plasmin and α2,-antiplasmin, its main inhibitor. Blood samples were obtained from 20 patients with prostatic carcinoma and benign prostatic hyperplasia. In three patients with carcinoma massive haematuria was observed. α2,-antiplasmin activity in patients with carcinoma was found to be lower than that in patients with benign prostatic hyperplasia. Plasminogen level in both groups was normal. Additionally, routine fibrinolysis parameters were evaluated which proved to be normal except for the bleeding patients. Apart from the decreased α2,-antiplasmin activity and plasminogen level, the latter group showed a reduced euglobulin lysis time (ELT), increased level of fibrin degradation products (FDP), prolonged kaolin-kephalin time (aPTT) and low platelet count. The altered values of the parameters are, presumably, the evidence of the activation of fibrinolysis. The authors believe that patients with prostatic carcinoma are at higher risk of developing bleeding that those with benign prostatic hyperplasia.
Keywords: prostatics carcinoma, Fibrinolysis, alpha2-antiplasmin, bleeding
Editorial
01 March 2024 : Editorial
Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-ThalassemiaDOI: 10.12659/MSM.944204
Med Sci Monit 2024; 30:e944204
In Press
21 Feb 2024 : Clinical Research
Potential Value of HSP90α in Prognosis of Triple-Negative Breast CancerMed Sci Monit In Press; DOI: 10.12659/MSM.943049
22 Feb 2024 : Review article
Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...Med Sci Monit In Press; DOI: 10.12659/MSM.943168
23 Feb 2024 : Clinical Research
A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...Med Sci Monit In Press; DOI: 10.12659/MSM.943732
26 Feb 2024 : Clinical Research
Predictive Value of Combined HbA1c and Neutrophil-to-Lymphocyte Ratio for Diabetic Peripheral Neuropathy in...Med Sci Monit In Press; DOI: 10.12659/MSM.942509
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952