04 May 2007
Analysis of family incidence of cleft lip and/or palate
Małgorzata Kot, Julia Kruk-JerominiMed Sci Monit 2007; 13(5): CR231-234 :: ID: 484603
Abstract
Background: The aim of the study was to analyze family incidence of clefts and to follow the relationship between the type of cleft in a child and in its parents as well as between the sex of the child and of the affected parent.
Material/Methods: The study comprised 540 children with cleft lip and/or palate with a positive family history of cleft. One hundred twenty-seven children were selected from this group whose mother or father had a cleft. In this group, the relationship between the type of cleft and the child’s and affected parent’s sex were analyzed.
Results: Two groups of genetic clefts were confi rmed, each with different risks of repetition: group I with cleft lip and/or palate and group II with isolated cleft palate. It was demonstrated that the type of cleft in a child depends not only on the type of cleft observed in the parent, but that there is also a
great risk of incidence of a cleft in sons of mothers with cleft lip (CL) or cleft lip and palate (CLP) or fathers with cleft lip (CL) and in daughters of mothers or fathers with cleft palate (CP).
Conclusions: 1. In 17% of children with cleft lip and/or palate, a positive family history was found. 2. The cleft type in a child depends not only on the type found in the mother or father, but also on the child’s sex.
Keywords: Cleft Lip - genetics, Child, Cleft Palate - genetics, Family, Pregnancy, Risk Factors
Editorial
01 March 2024 : Editorial
Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-ThalassemiaDOI: 10.12659/MSM.944204
Med Sci Monit 2024; 30:e944204
In Press
18 Mar 2024 : Clinical Research
Sexual Dysfunction in Women After Tibial Fracture: A Retrospective Comparative StudyMed Sci Monit In Press; DOI: 10.12659/MSM.944136
21 Feb 2024 : Clinical Research
Potential Value of HSP90α in Prognosis of Triple-Negative Breast CancerMed Sci Monit In Press; DOI: 10.12659/MSM.943049
22 Feb 2024 : Review article
Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...Med Sci Monit In Press; DOI: 10.12659/MSM.943168
23 Feb 2024 : Clinical Research
A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...Med Sci Monit In Press; DOI: 10.12659/MSM.943732
Most Viewed Current Articles
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952