Correlation of clinical and surgical findings to histological features (koilocytosis, papillary hyperplasia) suggesting papillomavirus involvement in the pathogenesis of cholesteatoma
Eleftherios Ferekidis, Thomas P. Nikolopoulos, John Yiotakis, Elisa Ferekidou, Dimitrios Kandiloros, Konstantina Papadimitriou, Antonios Tzangaroulakis
Med Sci Monit 2006; 12(9): CR368-371
Background:The clinical course of cholesteatoma is rather unpredictable, as some cases show aggressive development, while others have a mild, more ‘benign’ nature. The aim was to correlate the clinical course and surgical findings of cholesteatomas with histological features.
Material/Methods: The study included 45 patients with cholesteatoma, 29 of whom had surgically aggressive and 16 simple (not surgically aggressive)cholesteatoma. All patients underwent mastoid surgery and the cholesteatoma specimens were sent for histological examination.
Results: The clinical course of the cholesteatomas had a statistically significant association (p
Keywords: Humans, Female, Cholesteatoma, Middle Ear - virology, Adult, Hyperplasia - virology, Male, Middle Aged, Papillomaviridae, Papillomavirus Infections - pathology