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Prevention of motion sickness with rizatriptan: a double-blind, placebo-controlled pilot study

Dawn A. Marcus, Joseph M. Furman

Med Sci Monit 2006; 12(1): PI1-7

ID: 443201

Published: 2005-12-22


Background: Serotonergic triptan medications effectively reverse pain andassociated symptoms of migraine. Vestibular symptoms, including dizziness and vertigo, occur in aboutone-third of migraineurs. The most frequent and consistent balance symptom in migraineurs is motion sickness,which is experienced by about half of migraineurs and may be related to serotonergic influences. Thisdouble-blind, placebo-controlled, crossover pilot study was designed to test the hypothesis that pre-treatmentwith the serotonin agonist rizatriptan would prevent motion sickness provocation in headache-free migraineurs.Material/Methods: Ten healthy adult migraineurs (5 migrainous vertigo and 5 migraine without associatedvestibular symptoms) with a history of motion sickness were tested in three sessions: a baseline vestibularbattery and two motion sickness provocation sessions two hours following randomly ordered blinded pre-treatmentwith either oral rizatriptan 10 mg or placebo. Motion sickness was assessed using two standardized questionnaires.Results: Motion sickness scores were lower following pre-treatment with rizatriptan compared with placeboin subjects with migrainous vertigo. Rizatriptan did not affect motion sickness in migraineurs withoutvertigo. Otolith-ocular reflex sensitivity was reduced following pretreatment with rizatriptan in bothgroups. Conclusions: This is the first study in humans testing a triptan serotonin agonist as a preventivetool for motion sickness. Rizatriptan prevented the development of motion sickness and severe motionsickness symptoms in patients with migrainous vertigo. These pilot data suggest a possible role for serotoninin the development of motion sickness symptoms in migraineurs with migrainous vertigo.

Keywords: Cross-Over Studies, Triazoles - therapeutic use, Serotonin Receptor Agonists - therapeutic use, Placebos, Motion Sickness - physiopathology, Migraine Disorders - drug therapy, Middle Aged, Male, Humans, Female, Double-Blind Method, Adult, Tryptamines - therapeutic use



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