Age and sex as factors modifying the function of the blood-cerebrospinal fluidbarrier.
C Pakulski, L Drobnik, B MilloMed Sci Monit 2000; 6(2): CR314-318 :: ID: 428875
Abstract
INTRODUCTION: The aim of the study was to find out, if there was a differencein function of the blood/cerebrospinal fluid barrier (BCSFB) in females and males, and if those differencesintensify with age. MATERIAL AND METHODS: 120 patients of both sexes who underwent subarachnoideal anesthesiawere divided into 6 groups, 20 patients each, considering sex and age criteria. Samples of venous blood(5 ml) and cerebrospinal fluid (1 ml) were collected from every patient simultaneously; then albuminpermeability indexes (Qalb) were counted. The achieved results were compared using the t-Student testat the significance level of P < or = 0.05. RESULTS: The mean value of Qalb in patients aged 20-50 wassignificantly lower than in the group of patients aged 51-70, as well as in the group of patients over71. The difference between mean Qalb values in patients aged 51-70 and those aged over 71 was also statisticallysignificant. No statistically significant difference between mean Qalb values in females and in malesin the corresponding age groups was found. In every age group the value of albumin permeability indexwas lower in females. CONCLUSIONS: 1) The permeability of BCSFB increases with age. 2) There was no statisticallysignificant difference between the values of albumin permeability index in females and males in the correspondingage groups. The function of BCSFB in the corresponding age groups of males and females was the same.
Keywords: Sex Characteristics
Editorial
01 April 2024 : Editorial
Editorial: Forty Years of Waiting for Prevention and Cure of HIV Infection – Ongoing Challenges and Hopes for Vaccine Development and Overcoming Antiretroviral Drug ResistanceDOI: 10.12659/MSM.944600
Med Sci Monit 2024; 30:e944600
In Press
06 Mar 2024 : Clinical Research
Prevalence and Variation of Medical Comorbidities in Oral Surgery Patients: A Retrospective Study at Jazan ...Med Sci Monit In Press; DOI: 10.12659/MSM.943884
08 Mar 2024 : Clinical Research
Evaluation of Foot Structure in Preschool Children Based on Body MassMed Sci Monit In Press; DOI: 10.12659/MSM.943765
15 Apr 2024 : Laboratory Research
The Role of Copper-Induced M2 Macrophage Polarization in Protecting Cartilage Matrix in OsteoarthritisMed Sci Monit In Press; DOI: 10.12659/MSM.943738
07 Mar 2024 : Clinical Research
Knowledge of and Attitudes Toward Clinical Trials: A Questionnaire-Based Study of 179 Male Third- and Fourt...Med Sci Monit In Press; DOI: 10.12659/MSM.943468
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952