01 January 2001
Case of spinocerebellar ataxia type 1 showing high intensity lesions in the frontal white matter on T2-weighted magnetic resonance images.
Tomohiro Nakayama, Kiyokazu Nakayama, Yoshiko Takahashi, Kimie Ohkubo, Hideko Tobe, Masayoshi Soma, Yukio Ozawa, Katsuo Kanmatsuse, Makoto Nakamura, Takashi Hironaga, Yutaka Makizumi, Hiroshi NaguraMed Sci Monit 2001; 7(2): CS299-303 :: ID: 421145
Abstract
We report a case of genetically confirmed spinocerebellar ataxia type 1(SCA1) in which magnetic resonance imaging (MRI) demonstrated a high signal intensity on T2-weightedimages in the white matter of the frontal lobes. The patient was a 60-year-old Japanese man who complainedof gait instability and speech difficulties. He was diagnosed as having spinocerebellar ataxia at theage of 46. A CAG repeat number of the patient was 48/26. Brain MRI showed marked atrophy of the cerebellumand brain stem. The high-signal intensity lesions on T2-weighted MRI in the white matter of the frontallobes were evident in the periventricular regions. Such MRI abnormalities have not been described inSCA1 previously.
Keywords: SCA1, MRI, trinucleotide expansion, CAG repeat, autosomal dominant
Editorial
01 April 2024 : Editorial
Editorial: Forty Years of Waiting for Prevention and Cure of HIV Infection – Ongoing Challenges and Hopes for Vaccine Development and Overcoming Antiretroviral Drug ResistanceDOI: 10.12659/MSM.944600
Med Sci Monit 2024; 30:e944600
In Press
06 Mar 2024 : Clinical Research
Comparison of Outcomes between Single-Level and Double-Level Corpectomy in Thoracolumbar Reconstruction: A ...Med Sci Monit In Press; DOI: 10.12659/MSM.943797
21 Mar 2024 : Meta-Analysis
Economic Evaluation of COVID-19 Screening Tests and Surveillance Strategies in Low-Income, Middle-Income, a...Med Sci Monit In Press; DOI: 10.12659/MSM.943863
10 Apr 2024 : Clinical Research
Predicting Acute Cardiovascular Complications in COVID-19: Insights from a Specialized Cardiac Referral Dep...Med Sci Monit In Press; DOI: 10.12659/MSM.942612
06 Mar 2024 : Clinical Research
Enhanced Surgical Outcomes of Popliteal Cyst Excision: A Retrospective Study Comparing Arthroscopic Debride...Med Sci Monit In Press; DOI: 10.12659/MSM.941102
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952