01 January 2001
Plasma leptin concentrations in patients with Graves' disease with or without ophthalmopathy.
Metin Ozata, Gokhan Uckaya, Erol Bolu, Demet Corapcioglu, Necati Bingol, Caglayan I OzdemirMed Sci Monit 2001; 7(4): CR696-700 :: ID: 421083
Abstract
BACKGROUND: Recent studies have demonstrated that human preadipocyte fibroblastsin orbital connective tissues from patients with Graves' ophthalmopathy differentiate into cells resemblingadipocytes and acquire expression of leptin and functional thyroid stimulating hormone receptors. Thesefinding imply that leptin may play a role in the pathogenesis of Graves' ophthalmopathy. However, littleis known about plasma leptin concentration in patients with Graves' disease with or without ophthalmopathy.
MATERIAL AND METHODS: To investigate this relationship; 28 patients with active Graves' ophthalmopathy(19 female and 9 male, mean age: 32.7+/-10.5 years, mean BMI: 24.8+/-3.7 kg/m2) and 10 patients withoutophthalmopathy (6 female and 4 male, mean age: 24.6+/-5.6, mean BMI: 23.02+/-2.4 kg/m2) all with untreatedGraves' disease were included in the study at first diagnosis in our endocrinology out-patient clinic.Sex-, BMI- and age-matched twenty healthy subjects (13 female, 7 male, mean age: 31.9+/-10.0, mean BMI:24.2+/-3.0 kg/m2) were selected as a control group. Plasma leptin levels were measured by a RIA methodwith a sensitivity of 0.5 ng/ml.
RESULTS: Results showed any significant differences neither betweenpatients and controls (7.97+/-5.2 ng/ml vs. 7.83+/-3.7 ng/ml) nor between patients with or without Graves'ophthalmopathy (8.29+/-5.0 ng/ml vs. 7.06+/-5.8 ng/ml) (both P>0.05). Moreover, no correlation was foundbetween plasma leptin levels and ophthalmopathy index score, or proptosis.
CONCLUSIONS: Although effectsof local leptin production in the orbit cannot be excluded, our data suggest that circulating plasmaleptin does not have a significant direct influence on ophthalmopathy index score or pathophysiologyof Graves' ophthalmopathy.
Keywords: Graves, Leptin
Editorial
01 March 2024 : Editorial
Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-ThalassemiaDOI: 10.12659/MSM.944204
Med Sci Monit 2024; 30:e944204
In Press
18 Mar 2024 : Clinical Research
Sexual Dysfunction in Women After Tibial Fracture: A Retrospective Comparative StudyMed Sci Monit In Press; DOI: 10.12659/MSM.944136
21 Feb 2024 : Clinical Research
Potential Value of HSP90α in Prognosis of Triple-Negative Breast CancerMed Sci Monit In Press; DOI: 10.12659/MSM.943049
22 Feb 2024 : Review article
Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...Med Sci Monit In Press; DOI: 10.12659/MSM.943168
23 Feb 2024 : Clinical Research
A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...Med Sci Monit In Press; DOI: 10.12659/MSM.943732
Most Viewed Current Articles
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952