09 January 2002
Electron microscope investigation of the role of Chlamydia sp. in the process of rebuilding the arterial wall: Neoangiogenesis in atherosclerotic plaques in human cervical artery walls
Mieczyslaw Szostek, Grzegorz Opolski, Renata Celary-Walska, Tomasz Lazowski, Michal Walski, Paweł Andruszkiewicz, Mirosław RybaMed Sci Monit 2002; 8(1): BR30-38 :: ID: 420973
Abstract
BACKGROUND: The inflammatory process has an essential impact on the developmentof atherosclerosis. Three mechanisms are mentioned: 1) possibility of direct development of Chlamydiainfection in the vicinity of the blood vessel wall; 2) impact of persistent or recurrrent Chlamydia infectionon the increased blood concentration of risk factors for atherosclerosis; 3) an autoimmunological reaction.MATERIAL/METHODS: Electron microscope examinations were performed on specimens from atherosclerotic lesionsof the interior cervical arteries, collected from patients who had undergone endarterectomy. The materialcame from 8 patients (age from 58 to 72). The specimens were fixed for electron microscopy, and afterdehydration were immersed in Spurr resin. Ultrathin slices were examined under a transmission electronmicroscope. RESULTS: In the successive tested layers nearest the lumen of the vessel we found erythrocyticelements, fibrin, and lipid membranes. In deeper layers there were lymphocytic cells, monocytes, andmacrophages loaded with phagocyted lipid material. Under this layer we found in some specimens a coatingwhich had undergone mineralization: calcium structures and cholesterol were overlaid on a proteoglycanatebase. Smooth muscles cells had undergone the heaviest proliferation among the cells on artery wall. Inthe tested material we detected diversified morphological forms of Chlamydia sp. Particular attentionshould be drawn to the appearance of very young vessel forms, which suggests a process of angiogenesisin the atherosclerotic plaques. CONCLUSIONS: We found that one of the pathogens that may lead to atheroscleroticlesions is Chlamydia sp. The process of atherogenesis in cervical arteries is accompanied by angiogeneticprocesses.
Keywords: Arteries, Arteriosclerosis, Chlamydia, Endothelium, Vascular, Erythrocytes, Microscopy, Electron, Neovascularization, Physiologic
Editorial
01 April 2024 : Editorial
Editorial: Forty Years of Waiting for Prevention and Cure of HIV Infection – Ongoing Challenges and Hopes for Vaccine Development and Overcoming Antiretroviral Drug ResistanceDOI: 10.12659/MSM.944600
Med Sci Monit 2024; 30:e944600
In Press
15 Apr 2024 : Laboratory Research
The Role of Copper-Induced M2 Macrophage Polarization in Protecting Cartilage Matrix in OsteoarthritisMed Sci Monit In Press; DOI: 10.12659/MSM.943738
07 Mar 2024 : Clinical Research
Knowledge of and Attitudes Toward Clinical Trials: A Questionnaire-Based Study of 179 Male Third- and Fourt...Med Sci Monit In Press; DOI: 10.12659/MSM.943468
08 Mar 2024 : Animal Research
Modification of Experimental Model of Necrotizing Enterocolitis (NEC) in Rat Pups by Single Exposure to Hyp...Med Sci Monit In Press; DOI: 10.12659/MSM.943443
18 Apr 2024 : Clinical Research
Comparative Analysis of Open and Closed Sphincterotomy for the Treatment of Chronic Anal Fissure: Safety an...Med Sci Monit In Press; DOI: 10.12659/MSM.944127
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952