25 February 2002
Hepatic cirrhosis increases sensitivity of kidney to endotoxin in rats.
Ji-Yao Wang, Chi Zhang, Jian-Jun Liu, Ake Nilsson, Rui-Dong DuanMed Sci Monit 2002; 8(2): BR56-60 :: ID: 420918
Abstract
BACKGROUND: Renal failure in cirrhotic patients is a severe complicationand endotoxemia might be involved. We investigated the effect of endotoxin on renal function of cirrhoticrats and the potential protective role of N-acetylcysteine (NAC). MATERIAL/METHODS: Hepatic cirrhosiswas generated in a rat model by carbon tetrachloride. Both cirrhotic and normal rats were insulted byendotoxin intravenously, while another cirrhotic group was pre-treated with NAC. Blood urea nitrogen(BUN) and creatinine were assayed eight hours later. The changes in serum tumor necrosis factor-a (TNF-a)were assayed by ELISA. The histological changes in the kidney were observed after hematoxylin and eosinstaining. RESULTS: Endotoxin increased the BUN and creatinine levels in both normal and cirrhotic rats,with a much higher elevation in the latter group. TNF-a concentration was also increased by endotoxin;the changes are positively correlated with BUN and creatinine. NAC pretreatment significantly attenuatesthe effects of endotoxin on BUN, creatinine and TNF-a levels in cirrhotic rats with no improvement insystemic toxicity symptoms. There were no obvious histological changes in the kidney of these animals.CONCLUSIONS: Hepatic cirrhosis increased the sensitivity of renal function to endotoxemia, which maybe protected by NAC.
Keywords: Acetylcysteine, Endotoxins, Kidney, Liver Cirrhosis
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