11 March 2002
Role of fasting serum C-peptide as a predictor of cardiovascular risk associated with the metabolic X-syndrome.
Peter Haban, Robert Simoncic, Eva Zidekova, Lubomir OzdinMed Sci Monit 2002; 8(3): CR175-179 :: ID: 420907
Abstract
BACKGROUND: Insulin resistance with increased insulin and C-peptide levelsis the basis of the metabolic X-syndrome, so it is reasonable to expect them to be a good predictor ofassociated cardiovascular risk factors. MATERIAL/METHODS: A total of 29 patients (21 postmenopausal womenand 8 men) with type 2 diabetes mellitus (mean duration 14.6 years, 95% CI 11.9 to 17.3 years), all olderthan 50, were studied for possible links between fasting serum C-peptide levels and other vascular riskfactors. The mean value of the C-peptide in the group was 0.627 nmol/l (95% CI: 0.464 to 0.789 nmol/l).RESULTS: We found statistically significant correlations between C-peptide and triacylglycerols (TG;r=0.474; p=0.009), HDL-cholesterol (inverse; r = -0.567; p = 0.001) and various lipoprotein ratios: atherogenicindex (= total/HDL cholesterol: r = 0.599; p = 0.0006) or TG/HDL (r = 0.587; p = 0.0008). C-peptide alsocorrelated with the body mass index (BMI: r = 0.519; p= 0.004) and leptin (r = 0.492; p = 0.007). Afterthe coefficient CpG (C-peptide x fasting glycemia) was introduced, the correlations with lipoproteinsbecame even stronger. CONCLUSIONS: We suggest that elevated (fasting) serum C-peptide levels constitutea clinically important marker of the cardiovascular risks associated with the metabolic X-syndrome. Itcan be used as an effective tool for the early detection of diabetic patients at particular risk foratherosclerotic cardiovascular diseases and needing early preventive measures or aggressive treatment.
Keywords: C-peptide, Cardiovascular Diseases, Diabetes Mellitus, Type 2, Hyperlipoproteinemia, Insulin, Insulin Resistance, Lipoproteins, Metabolic Syndrome X, Peptides, Postmenopause, Risk Factors
Editorial
01 March 2024 : Editorial
Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-ThalassemiaDOI: 10.12659/MSM.944204
Med Sci Monit 2024; 30:e944204
In Press
18 Mar 2024 : Clinical Research
Sexual Dysfunction in Women After Tibial Fracture: A Retrospective Comparative StudyMed Sci Monit In Press; DOI: 10.12659/MSM.944136
21 Feb 2024 : Clinical Research
Potential Value of HSP90α in Prognosis of Triple-Negative Breast CancerMed Sci Monit In Press; DOI: 10.12659/MSM.943049
22 Feb 2024 : Review article
Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...Med Sci Monit In Press; DOI: 10.12659/MSM.943168
23 Feb 2024 : Clinical Research
A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...Med Sci Monit In Press; DOI: 10.12659/MSM.943732
Most Viewed Current Articles
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952