Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

18 June 2002

Cardiotoxicity following different doses and schedules of 5-fluorouracil administrationfor malignancy -- a survey of 427 patients.

Maria Vadiaka, Michalis Efremidis, Andreas Zinelis, Christos Kosmas, Nicolas Tsavaris, Dimitris Beldecos, Dimitris Sakelariou, Christos Koufos, George Stamatelos

Med Sci Monit 2002; 8(6): PI51-57 :: ID: 420798

Abstract

BACKGROUND: Although cardiotoxicity associated with 5-Fluorouracil (5-FU)administration is infrequent, there are case reports of acute coronary syndromes. We report on patientsundergoing 5-FU chemotherapy who developed cardiac symptoms during its administration.MATERIAL/METHODS:In patients receiving 5-FU who experienced cardiac-related symptoms, ECG and serum cardiac enzyme determinationwere performed. If cardiotoxicity was detected, 5-FU infusion was interrupted, and the patients receivedsublingual nitrates and cardiac monitoring, while patients with more than 2-fold elevated enzyme levelswere monitored in a coronary care unit for at least 72 hours. In cases of acute myocardial infarction,5-FU was terminated.RESULTS: Of 427 patients entering the study, 17 (4%) developed clinical symptomsand ECG abnormalities indicating 5-FU cardiotoxicity. Patients with continuous infusion (c.i.) of 5-FUhad a higher incidence of cardiotoxicity (12/197, 6%) than the remaining (5/235, 2.1%) (p=0.067), butmore toxicity was encountered in patients with c.i. of 5-FU+LV for 24 hours for 5 days than in patientswith the same regimen of 5-FU without LV (p

Keywords: Antimetabolites, Antineoplastic, Dose-Response Relationship, Drug, Drug Administration Schedule, Electrocardiography, Fluorouracil, Heart, Neoplasms

Add Comment 0 Comments

Editorial

01 March 2024 : Editorial  

Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-Thalassemia

Dinah V. Parums

DOI: 10.12659/MSM.944204

Med Sci Monit 2024; 30:e944204

0:00

In Press

18 Mar 2024 : Clinical Research  

Sexual Dysfunction in Women After Tibial Fracture: A Retrospective Comparative Study

Med Sci Monit In Press; DOI: 10.12659/MSM.944136  

0:00

21 Feb 2024 : Clinical Research  

Potential Value of HSP90α in Prognosis of Triple-Negative Breast Cancer

Med Sci Monit In Press; DOI: 10.12659/MSM.943049  

22 Feb 2024 : Review article  

Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943168  

23 Feb 2024 : Clinical Research  

A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943732  

Most Viewed Current Articles

16 May 2023 : Clinical Research  

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

17 Jan 2024 : Review article  

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750