01 June 2005 : Original article
Gait characteristics in patients with type 2 diabetes; improvement after administration of rosiglitazone
Jerrold S. Petrofsky, Scott Lee, Maria L. CuneoMed Sci Monit 2005; 11(6): PI43-51 :: ID: 16513
Abstract
Summary
Background: Gait is impaired in people with type 2 diabetes. An insulin sensitizer, rosiglitazone(RSG) has promise to reverse some of the circulatory impairments seen in diabetes. The hypothesis to be tested
was if RSG would improve gait in patients with diabetes.
Material/Methods: Gait in 30 controls and 25 subjects with Type 2 diabetes was examined (10 subjects with diabetes were placed on rosiglitazone (4 mg/day) for 6 months, a PPAR-g ligand known to improve peripheral circulation, to asses any improvements in gait). Gait was analyzed by video, shoe sensors, accelerometers
and electromyogram of the medial gastrocnemius and tibialis anterior muscles during the initiation of gait, steady state gait and turns.
Results: Subjects with diabetes had almost double the movement at the knee in both the fl exion-extension and lateral directions than did control subjects. For example, for fl exion-extension at the knee
during constant velocity gait in a linear path, subjects with diabetes averaged a force of 1.91±0.29 g whereas control subjects only averaged 1.26±0.27 g, these differences were signifi cant (p
Keywords: Diabetes Mellitus, Type 2 - drug therapy, Body Mass Index, Diabetes Mellitus, Type 2 - physiopathology, Gait - physiology, H-Reflex, Hypoglycemic Agents - therapeutic use, Knee Joint - physiopathology, Muscle, Skeletal - physiopathology, Reaction Time, Reference Values, Shoes, Thiazolidinediones - therapeutic use, Video Recording
Editorial
01 March 2024 : Editorial
Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-ThalassemiaDOI: 10.12659/MSM.944204
Med Sci Monit 2024; 30:e944204
In Press
21 Feb 2024 : Clinical Research
Potential Value of HSP90α in Prognosis of Triple-Negative Breast CancerMed Sci Monit In Press; DOI: 10.12659/MSM.943049
22 Feb 2024 : Review article
Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...Med Sci Monit In Press; DOI: 10.12659/MSM.943168
23 Feb 2024 : Clinical Research
A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...Med Sci Monit In Press; DOI: 10.12659/MSM.943732
26 Feb 2024 : Clinical Research
Predictive Value of Combined HbA1c and Neutrophil-to-Lymphocyte Ratio for Diabetic Peripheral Neuropathy in...Med Sci Monit In Press; DOI: 10.12659/MSM.942509
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952