01 June 2005 : Original article
Preliminary evidence of genetic anticipation in type 2 diabetes mellitus
Subhashini Yaturu, Juanita F. Bridges, Ramasubba Reddy DhanireddyMed Sci Monit 2005; 11(6): CR262-265 :: ID: 16499
Abstract
Summary
Background: The term “anticipation” in genetic diseases refers to earlier age at onset and/or increased severity
in successive generations. Several diseases with genetic anticipation include rheumatoid arthritis,Crohn’s disease, Schizophrenia, Graves’ disease and several other neuropsychiatric disorders. The
im of the present study was to investigate whether genetic anticipation may occur in diabetes.
Material/Methods: The medical records of 485 subjects with type 2 diabetes, seen in the Diabetes Clinic were screened for subjects with a family history of diabetes and also aware of a defi nite date of diagnosis for both the subject and their family member. Ninety-six parent-child pairs with a known defi nite date of diagnosis of type 2 diabetes were identifi ed and the age at onset of diabetes between two parentchild generations was compared.
Results: The age at diagnosis of the subjects with positive family history of diabetes was lower than those with no family history of diabetes (48.82±12 vs. 56.18±13; p
Keywords: Diabetes Complications - epidemiology, Diabetes Complications - genetics, Obesity - epidemiology, Adoption, Age of Onset, Diabetes Complications - genetics, Diabetes Mellitus, Type 2 - genetics, Medical Records, Nuclear Family, Obesity - epidemiology
Editorial
01 April 2024 : Editorial
Editorial: Forty Years of Waiting for Prevention and Cure of HIV Infection – Ongoing Challenges and Hopes for Vaccine Development and Overcoming Antiretroviral Drug ResistanceDOI: 10.12659/MSM.944600
Med Sci Monit 2024; 30:e944600
In Press
05 Mar 2024 : Clinical Research
Role of Critical Shoulder Angle in Degenerative Type Rotator Cuff Tears: A Turkish Cohort StudyMed Sci Monit In Press; DOI: 10.12659/MSM.943703
06 Mar 2024 : Clinical Research
Comparison of Outcomes between Single-Level and Double-Level Corpectomy in Thoracolumbar Reconstruction: A ...Med Sci Monit In Press; DOI: 10.12659/MSM.943797
21 Mar 2024 : Meta-Analysis
Economic Evaluation of COVID-19 Screening Tests and Surveillance Strategies in Low-Income, Middle-Income, a...Med Sci Monit In Press; DOI: 10.12659/MSM.943863
10 Apr 2024 : Clinical Research
Predicting Acute Cardiovascular Complications in COVID-19: Insights from a Specialized Cardiac Referral Dep...Med Sci Monit In Press; DOI: 10.12659/MSM.942612
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952