02 May 2003
Memory formation in trained Aplysia is mediated by activation of PARP-1
M. Cohen-Armon, L. Visochek, A. Katzoff, A. Susswein, R. Klein, M. Valbrun, J. Guan, J. SchwartzMed Sci Monit 2003; 9(1): 13-0 :: ID: 15060
Abstract
We found that the post-translational modification of chromatin-bound proteins by polyADP-ribosylation mediates expression of long-term memory in the marine mollusk Aplysia, trained by either associative or non-associative learning. Sensitization of defensive reflexes and learning that a food is inedible are representative examples of non-associative and associative learning, respectively. For defensive reflexes, a short-term memory lasts for minutes, and long-term memory lasts days to weeks. For learning that food is inedible, a single 30 min training session causes a long-term memory maintained for 1 to 7 days. We found that PARP-1 activation is strongly correlated with long-term modifications in sensory-to-motor synapses, controlling the tail-withdrawal reflex of Aplysia. PARP-1 was activated in nuclei of sensory neurons in the pleural ganglia by stimulation causing long-term facilitation (LTF). Stimulation causing a short-term facilitation (STF) did not activate PARP-1, and long-term depression (LTD) suppressed polyADP-ribosylation in sensory neurons in the pleural ganglia. PARP-1 was similarly activated in the cerebral and buccal ganglia controlling feeding in Aplysia trained with inedible food. Moreover, treatment with 3-AB (1 mM) blocked exclusively the long-term memory of the trained Aplysia, without affecting their short-term memory. These findings are the first evidence relating the post-translational modification of nuclear proteins by polyADP-ribosylation to the formation of long-term synaptic plasticity and to behaviorally expressed long-term memory.
Keywords: polyADP-ribosylation, PARP-1, synaptic plasticity, learning and memory in trained aplysia
Editorial
01 April 2024 : Editorial
Editorial: Forty Years of Waiting for Prevention and Cure of HIV Infection – Ongoing Challenges and Hopes for Vaccine Development and Overcoming Antiretroviral Drug ResistanceDOI: 10.12659/MSM.944600
Med Sci Monit 2024; 30:e944600
In Press
21 Mar 2024 : Meta-Analysis
Economic Evaluation of COVID-19 Screening Tests and Surveillance Strategies in Low-Income, Middle-Income, a...Med Sci Monit In Press; DOI: 10.12659/MSM.943863
10 Apr 2024 : Clinical Research
Predicting Acute Cardiovascular Complications in COVID-19: Insights from a Specialized Cardiac Referral Dep...Med Sci Monit In Press; DOI: 10.12659/MSM.942612
06 Mar 2024 : Clinical Research
Enhanced Surgical Outcomes of Popliteal Cyst Excision: A Retrospective Study Comparing Arthroscopic Debride...Med Sci Monit In Press; DOI: 10.12659/MSM.941102
06 Mar 2024 : Clinical Research
Prevalence and Variation of Medical Comorbidities in Oral Surgery Patients: A Retrospective Study at Jazan ...Med Sci Monit In Press; DOI: 10.12659/MSM.943884
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952