01 February 2005
Tumor marker CA-125 as an evaluator and response indicator in ovarian cancer: its quantitative correlation with tumor volume
Pratik Kumar, Madan Mohan Rehani, Lalit Kumar, Raju Sharma, Neerja Bhatla, Rama Chaudhry, Sanjay Thulkar, K. Ramaiyer Sundaram, Neeta KumarMed Sci Monit 2005; 11(2): CR84-89 :: ID: 14163
Abstract
Background:The tumor marker Cancer Antigen 125 (CA 125), though not ovarian cancer specific, is widely used for the evaluation of suspected and under-treated ovarian cancer. Many studies show that serum CA 125 level demonstrates ovarian tumor burden and its response, but they lack quantitative correlation between the two. Instead, they rely on clinical or radiological assessment of gross tumor burden. This study examines ovarian tumor volumes and corresponding serum CA 125 values before and during chemotherapy.Material/Methods:Ovarian tumor volume was measured by CT scans at pre-chemotherapy and after each cycle of chemotherapy in 15 patients. Blood serum CA 125 was determined on the days of CT scans using a one-step immunoenzymatic assay.Results:There was no statistically significant correlation (r=0.18, p>0.05) between ovarian tumor volumes and CA 125 among patients at pre-chemotherapy or any subsequent time. In individual patients, the reduction or increase in tumor volume correlated with the corresponding CA 125 values during chemotherapy in 85% (12 out of 14) of patients. Mean CA 125 halving time was 44.1 days, which correlated with tumor halving time (r=0.63, p
Keywords: CA-125 Antigen - blood, Ovarian Neoplasms - blood, CA-125 Antigen - blood, Ovarian Neoplasms - pathology, Time Factors, Tomography Scanners, X-Ray Computed
Editorial
01 April 2024 : Editorial
Editorial: Forty Years of Waiting for Prevention and Cure of HIV Infection – Ongoing Challenges and Hopes for Vaccine Development and Overcoming Antiretroviral Drug ResistanceDOI: 10.12659/MSM.944600
Med Sci Monit 2024; 30:e944600
In Press
05 Mar 2024 : Clinical Research
Role of Critical Shoulder Angle in Degenerative Type Rotator Cuff Tears: A Turkish Cohort StudyMed Sci Monit In Press; DOI: 10.12659/MSM.943703
06 Mar 2024 : Clinical Research
Comparison of Outcomes between Single-Level and Double-Level Corpectomy in Thoracolumbar Reconstruction: A ...Med Sci Monit In Press; DOI: 10.12659/MSM.943797
21 Mar 2024 : Meta-Analysis
Economic Evaluation of COVID-19 Screening Tests and Surveillance Strategies in Low-Income, Middle-Income, a...Med Sci Monit In Press; DOI: 10.12659/MSM.943863
10 Apr 2024 : Clinical Research
Predicting Acute Cardiovascular Complications in COVID-19: Insights from a Specialized Cardiac Referral Dep...Med Sci Monit In Press; DOI: 10.12659/MSM.942612
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952