01 May 2004
Conjunctival and tear film changes after vitamin C and E administration in non-insulin dependent diabetes mellitus
Vasileios Peponis, Stefanos Bonovas, Amalia Kapranou, Evangelia Peponi, Kalitsa Filioussi, Christina Magkou, Nikolaos M. SitarasMed Sci Monit 2004; 10(5): CR213-217 :: ID: 11649
Abstract
Background:The purpose of our research was to investigate the effect of supplementation with vitamin C and E on ocular surface cytology specimens and related parameters in diabetic patients.Material/Methods: 60 patients were enrolled in the study. The patients were given vitamin C (1000 mg/day) and vitamin E (400 IU/day) for 10 days. Conjunctival brush cytology specimens were obtained before and after treatment. Schirmer tests, break-up time and ocular ferning tests were also performed.Results: Goblet cell densities were 50 cells/per field before and 59 cells/per field after supplementation (p=0.002). The stage of squamous metaplasia was 1.12±0.42 before and 0.88I0.41 after supplementation (p=0.011). The changes were accompanied with improved values for the Schirmer test (p<0.001), break up time (p=0.001), and ocular ferning (p<0.001).
Conclusions: Diabetes mellitus is associated with increased oxidative stress. Our study suggests that supplementation with antioxidant vitamins C and E probably plays an important role in improving the ocular surface milieu.
Keywords: Diabetes Mellitus, Type 2 - drug therapy, Antioxidants - metabolism, Ascorbic Acid - therapeutic use, Conjunctiva - drug effects, Conjunctival Diseases - pathology, Diabetes Mellitus, Type 2 - drug therapy, Goblet Cells - metabolism, Tears - drug effects, Time Factors, Vitamin E - therapeutic use
Editorial
01 April 2024 : Editorial
Editorial: Forty Years of Waiting for Prevention and Cure of HIV Infection – Ongoing Challenges and Hopes for Vaccine Development and Overcoming Antiretroviral Drug ResistanceDOI: 10.12659/MSM.944600
Med Sci Monit 2024; 30:e944600
In Press
08 Mar 2024 : Clinical Research
Evaluation of Foot Structure in Preschool Children Based on Body MassMed Sci Monit In Press; DOI: 10.12659/MSM.943765
15 Apr 2024 : Laboratory Research
The Role of Copper-Induced M2 Macrophage Polarization in Protecting Cartilage Matrix in OsteoarthritisMed Sci Monit In Press; DOI: 10.12659/MSM.943738
07 Mar 2024 : Clinical Research
Knowledge of and Attitudes Toward Clinical Trials: A Questionnaire-Based Study of 179 Male Third- and Fourt...Med Sci Monit In Press; DOI: 10.12659/MSM.943468
08 Mar 2024 : Animal Research
Modification of Experimental Model of Necrotizing Enterocolitis (NEC) in Rat Pups by Single Exposure to Hyp...Med Sci Monit In Press; DOI: 10.12659/MSM.943443
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952