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Published: 2014-09-18

Prognostic Role of MicroRNA-21 in Gastric Cancer: a Meta-Analysis

Zhenqiang Wang, Qiang Cai, Zhaoyan Jiang, Bingya Liu, Zhenggang Zhu, Chen Li

(Department of Surgery, Shanghai Institute of Digestive Surgery, Shanghai Key Laboratory of Gastric Neoplasms, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China (mainland))

Med Sci Monit 2014; 20:1668-1674

DOI: 10.12659/MSM.892096


Background: Mounting evidence shows that microRNAs may be useful as prognostic biomarkers of gastric cancer. The aim of this meta-analysis was to summarize the predictive role of miR-21 for survival in patients with gastric cancer and to verify the association between expression of miR-21 and clinical characteristics.
Material and Methods: All the eligible studies were searched by PubMed and EMBASE and clinical characteristics and survival results were extracted. Then a meta-analysis was carried out to clarify the prognostic role of the miR-21 expression in different subgroups.
Results: We included 8 studies dealing with gastric cancer in this meta-analysis. For overall survival, the pooled hazard ratio of higher miR-21 expression in tumor tissue was 2.00 (95% CI: 1.39–2.88, P<0.01), which could significantly predict poorer survival in gastric cancer patients. Importantly, subgroup analysis suggested that higher expression of miR-21 correlated with tumor differentiation 0.42 (95% CI: 0.25–0.70 p<0.01), lymph node metastasis 6.39(95% CI: 3.11–13.14, P<0.01), and TNM stage 0.38 (95% CI: 0.21–0.67, P<0.01).
Conclusions: This meta-analysis indicates that miR-21 detection has a prognostic value in patients with gastric cancer. In addition, overexpression of miR-21 is associated with worse tumor differentiation, lymph node metastasis, and TNM stage.

Keywords: MicroRNAs, Prognosis, Stomach Neoplasms




Published: 2014-09-17

DPP-4 Inhibitors Improve Liver Dysfunction in Type 2 Diabetes Mellitus


Ippei Kanazawa, Ken-ichiro Tanaka, Toshitsugu Sugimoto

Med Sci Monit 2014; 20:1662-1667

DOI: 10.12659/MSM.890989

Published: 2014-09-16

Polymorphism of ABCB1/MDR1 C3435T in Children and Adolescents with Partial Epilepsy is due to Different C...


Ewa Emich-Widera, Wirginia Likus, Beata Kazek, Aleksander L. Sieroń, Ksymena Urbanek

Med Sci Monit 2014; 20:1654-1661

DOI: 10.12659/MSM.890633