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eISSN: 1643-3750

Published: 2017-07-25

Correlation Between Circulating Tumor DNA Levels and Response to Tyrosine Kinase Inhibitors (TKI) Treatment in Non-Small Cell Lung Cancer

Zhangjing Wei, Wenyue Wang, Zitan Shu, Xue Zhou, Yanfang Zhang

(Department of Diagnostic Medicine, JingMen No. 1 People’s Hospital, JingMen, Hubei, China (mainland))

Med Sci Monit 2017; 23:3627-3634

DOI: 10.12659/MSM.902265

BACKGROUND: Clinical monitoring of EGFR-positive NSCLC patients is important to gauge treatment response. The current study addresses the usage of circulating tumor DNA (ctDNA) as a prognostic marker during treatment of first-generation TKIs.
MATERIAL AND METHODS: Serial samplings of peripheral blood from 200 EGFR-positive NSCLC patients were taken. Baseline ctDNA quantification was conducted by digital droplet PCR before TKI treatment was administered and compared to primary biopsies. Thereafter blood sampling at different treatment cycles were measured and assessed for its prognostic and predictive value.
RESULTS: ctDNA was successfully detected in a number of patients and overall concordance rate was 84%. Importantly, we observed a strong correlation to ctDNA increase with disease progression using radiographic scans. In addition to survival analysis, we noted patients with the largest ctDNA variations had worst outcome. A significant number of EGFR patients during treatment developed a secondary mutation T790M and this cohort had worst survival outcome as well.
CONCLUSIONS: Our study demonstrated a highly associative relation of ctDNA to NSCLC patients during treatment that can be utilized to gauge treatment response. CtDNA is an attractive means compared with conventional core needle biopsies and presents new methods for accurately profiling NSCLC disease progression.

Keywords: Biopsy, Carcinoma, Non-Small-Cell Lung, Genes, erbB-1, Treatment Outcome

Published: 2017-07-25

Surgery for Infective Endocarditis: Outcomes and Predictors of Mortality in 360 Consecutive Patients

Mina Farag, Tobias Borst, Anton Sabashnikov, Mohamed Zeriouh, Bastian Schmack, Rawa Arif, Carsten J. Beller, Aron-Frederik Popov, Klaus Kallenbach, Arjang Ruhparwar, Pascal M. Dohmen, Gábor Szabó, Matthias Karck, Alexander Weymann

Med Sci Monit 2017; 23:3617-3626

DOI: 10.12659/MSM.902340

Published: 2017-07-24

Fork Head Box Class O1 (FOXO1) Activates Bim Expression to Mediate Cardiac Apoptosis in Chronic Intermitt...

Guangcai Li, Meng Jin, Yuan He, Jie Ren, Minghua Zhang, Yilin Chen, Xiong Lan, Jianhua Zhong, Huiguo Liu

Med Sci Monit 2017; 23:3603-3616

DOI: 10.12659/MSM.905210