Logo




Plant-Animal Research Competition

Four Awards ($1,500 each) + publication expenses

We are announcing a competition for external investigator reports dealing with plant-animal communications, which influence animal/human tissues. Eligible studies can vary in their methodology, but state-of-the-art research submissions are encouraged.

Awards Guidelines and Program:
  1. Four Awards granted ($1,500 each) + reimbursement of publication expenses
  2. All reports prepared according to the... read more


Published: 2014-10-02

Adiponectin Abates Atherosclerosis by Reducing Oxidative Stress

Xuemei Wang, Hongwei Pu, Chuang Ma, Tao Jiang, Qin Wei, Chun Zhang, Mingjun Duan, Xi Shou, Lipin Su, Jianlong Zhang, Yining Yang

(Xinjiang Key Laboratory of Medical Animal Model Research, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China (mainland))

Med Sci Monit 2014; 20:1792-1800

DOI: 10.12659/MSM.892299


Background: We investigated whether the anti-atherosclerosis of adiponectin (APN) relates to the reduction of oxidative stress. We observed the overexpression of adiponectin gene with different titers on atherosclerosis (AS) models of high-fat apolipoprotein E-deficient (ApoE–/–) mice.
Material and Methods: We divided 48 male ApoE–/– mice into 4 groups: control group, high-fat diet group, low adiponectin group, and high adiponectin group. The low and high adiponectin group mice were treated with recombinant adenovirus expressing mice adiponectin (Ad-APN) with low-dose adiponectin 1.0×108 p.f.u. and high-dose adiponectin 5.0×108 p.f.u. via the tail every 2 weeks and given a high-fat diet for the last 8 weeks. On the 14th day after injection, blood samples were obtained from the vena cava.
Results: Along with increased serum adiponectin, serum superoxide dismutase (SOD) activity increased (P<0.05) and concentration of malondialdehyde (MDA) was decreased (P<0.05). Levels of total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-C) were decreased, especially TC and LDL-C (P<0.05). A real-time fluorescent quantitative polymerase chain reaction test was used to analyze levels of mRNA expression for endothelial nitric oxide synthase (eNOS) and adiponectin in the aorta. Along with increased adiponectin, the mRNA expression of eNOS in the aorta was increased significantly (P<0.05). The lesion formation in the aortic sinus was inhibited by 25% and 31% in the low-APN group and high-APN group, respectively (P<0.05). Along with the increase of adiponectin doses, the damage of atherosclerosis... read more

Keywords: Adiponectin, atherosclerosis, Nitric Oxide Synthase Type III, Oxidative Stress, Superoxide Dismutase




Published: 2014-10-02

Diffusion Tensor Imaging of Spinocerebellar Ataxia Type 12


Haitao Li, Jingjing Ma, Xiaoning Zhang

Med Sci Monit 2014; 20:1783-1791

DOI: 10.12659/MSM.891104

Published: 2014-10-01

Reference Intervals for Total Bilirubin, ALT, AST and Creatinine in Healthy Chinese Elderly


Guo-ming Zhang, Yong-jie Xia, Xu-xiao Guo, Bao-lin Zhu, Gao-ming Zhang, Xiao-bo Ma, Hong Yu, Hong-jian Wang, Guang-sheng Wang, Li Yang, Ye-ting Zhou

Med Sci Monit 2014; 20:1778-1782

DOI: 10.12659/MSM.892148