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Plant-Animal Research Competition

Four Awards ($1,500 each) + publication expenses

We are announcing a competition for external investigator reports dealing with plant-animal communications, which influence animal/human tissues. Eligible studies can vary in their methodology, but state-of-the-art research submissions are encouraged.

Awards Guidelines and Program:
  1. Four Awards granted ($1,500 each) + reimbursement of publication expenses
  2. All reports prepared according to... read more


Published: 2014-11-26

Evidence for Using Alendronate to Treat Adult Avascular Necrosis of the Femoral Head: A Systematic Review

Ru-Bin Luo, Tiao Lin, Hui-Ming Zhong, Shi-Gui Yan, Jian-An Wang

(Department of Emergency Medicine, Research Institute of Emergency Medicine, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China (mainland))

Med Sci Monit 2014; 20:2439-2447

DOI: 10.12659/MSM.891123


Abstract: Osteonecrosis or avascular osteonecrosis (AVN) of the femoral head is a devastating multifactorial disease that affects 20 000 persons each year in the United States. The purpose of this systematic review was to determine the efficacy and safety of alendronate for adult AVN during short- and long-term follow-up. Electronic databases were searched for randomized or nonrandomized clinical trials, cohort, case-control studies, and series of cases in which alendronate was used for treatment of adult AVN of the femoral head. Relevant articles with adequate data on reduction of pain, improvement of articular function, slowing of bone collapse progression, or need for total hip arthroplasty (THA) were included after applying inclusion and exclusion criteria. Eight articles involving 788 hips with evidence level 1b to 3b were included in this systematic review. Most studies suggested a positive short-term efficacy of alendronate treatment in reducing pain, improving articular function, slowing of bone collapse progression, and delaying the need for THA for adult AVN patients. The favorable long-term results were also presented in those treated patients after 10-year follow-up. In addition, there were no severe adverse effects associated with alendronate treatment observed during short- and long-term follow-up, and most of the included studies suggested use of alendronate in early AVN with small necrotic lesion to achieve better outcomes. The findings support consideration of alendronate use for adult AVN, particularly with early stage and small necrotic size. The lack of large-scale, randomized, and double-blind studies justifies new studies to demonstrate the d... read more

Keywords: alendronate, Femur Head Necrosis, Review Literature as Topic




Published: 2014-11-26

Urethral Reconstruction with Tissue-Engineered Human Amniotic Scaffold in Rabbit Urethral Injury Models


Fuli Wang, Tao Liu, Lijun Yang, Geng Zhang, Heliang Liu, Xiaomin Yi, Xiaojian Yang, Tzu-yin Lin, Weijun Qin, Jianlin Yuan

Med Sci Monit 2014; 20:2430-2438

DOI: 10.12659/MSM.891042

Published: 2014-11-25

Low Paraoxonase 1 Arylesterase Activity and High von Willebrand Factor Levels are Associated with Severe ...


Jieying Ding, Qizhi Chen, Xing Zhuang, Zhilei Feng, Lili Xu, Fuxiang Chen

Med Sci Monit 2014; 20:2421-2429

DOI: 10.12659/MSM.890911